Developmental changes in mRNA expression in immune-associated cells of intestinal tract of broiler chickens after hatch and by dietary modification
2007
Miyazaki, Y.(Tohoku Univ., Sendai (Japan)) | Takahashi, K. | Akiba, Y.
Developmental changes in the immune-related cells of the gut during the first 2 weeks post hatching were determined in broiler chickens fed a corn-soybean meal (CS) based diet, a semi-purified diet with high fat (HF) and a high carbohydrate (HC) diet. The expression of CD3 and interferon-gamma (IFN-gamma) mRNA increased during 3-7 days of age. When the chicks were fed the CS diet, the expression of interleukin-2 mRNA in the foregut did not increase with age. The expression of iNOS mRNA was lowered at 3 days of age in the fore-and mid gut but the expression was constant at the other days of age, TLR-2 mRNA expression increased in three section of the gut during 3-7 days of age. while TLR-4 expression increased during 0-3 days of age. Chicks fed the HC diet showed higher interleukin-2 but lower IFN-gamma mRNA expression than birds fed the CS diet. Feeding the HF diet tended to decrease the expressions determined. These findings suggest that the functional maturation of the T cell does not always correlate with an increase in T cell numbers, maturation of innate immunity may occur earlier than that of T cells and possibly the dietary composition modifies the developmental pattern.
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