The coantioxidative effects of carboxyethyl-6-hydroxychromans and alpha-tocopherol
2007
Uto Kondo, H.(Ochanomizu Univ., Tokyo (Japan). Inst. of Environmental Science for Human Life) | Kiyose, C. | Ohmori, R. | Saito, H. | Taguchi, C. | Kishimoto, Y. | Machida, N. | Hasegawa, M. | Yoshioka, E. | Saita, E. | Hirata, Y. | Igarashi, O. | Kondo, K.
Alpha-Tocopherol (alpha-Toc) is abundant in LDL and thought to prevent the oxidation of LDL together with various water-soluble antioxidants. Recently, it was reported that alpha-Toc and gamma-Toc metabolites, alpha-carboxyethyl-6-hydroxychromans (CEHC) and gamma-CEHC, are water-soluble antioxidants. In this study, we investigated the interaction between alpha-Toc and CEHC against 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) radicals and LDL oxidation. We administered 600 mg of alpha-Toc to healthy male volunteers to obtain LDL including high levels of alpha-Toc before antioxidant administration. The alpha-Toc content of their LDL was increased after consumption at 24 h (18.3 microg/mL) above the level before consumption (6.6 microg/mL). The lag time of LDL at 24 h after alpha-Toc consumption (alpha-Toc rich LDL) with alpha-CEHC (98.5+-8.2 min) or gamma-CEHC (101.3+-9.0 min) was longer than that of only alpha-Toc-rich LDL (78.1+-9.0 min).
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