Development of simple method for estimating results of risk characterization in initial assessment of health risk of chemicals in Japan
2007
Yoshida, K.(National Inst. of Advanced Industrial Science and Technology Tsukuba, Ibaraki (Japan)) | Teguchi, N.
Lately, initial assessments for human and ecological risks of chemicals are performed by the Japanese government and several institutions. However, due to lack of information regarding hazard and exposure for a large number of chemicals, only a limited number of them have been assessed to date. It is, therefore, important to develop a simple method to estimate the results of risk characterization in initial assessment of chemicals with limited available information. In this study, we identified the important chemical-specific factors affecting the results of characterization for human health risks using environmental fate models and correlated such factors with the results of characterization by multiple logistic regression analysis. The results indicated that multiple logistic regression models had a good possibility of characterizing health risk via inhalation route on the basis of no observed adverse effect level (NOAEL), emission rate, vapor pressure, octanol/water partition coefficient (Kow), and atmospheric degradation half life, and also the risk via oral route on the basis of NOAEL, emission rate, Kow, and biodegradability. Further improvement of regression models will allow us to screen rapidly chemicals for which detailed assessment is required.
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