Rhei Rhizoma Extracts Have Antiproliferative Properties and Differential Effects on NO Production in Macrophages
2006
Pyo, S.K. (Sungkyunkwan University, Suwon, Republic of Korea) | Son, E.W. (Kangwon National University, Chuncheon, Republic of Korea), E-mail: ehson@kangwon.ac.kr
Recently, Rhei Rhizoma extracts (RRE) have begun to receive more attention as potential biological response modifiers. In the present study, we studied the antiproliferative effect of RRE on tumor cells and the effect of RRE on macrophage function. A variety of tumor cells and macrophages were treated with RRE at various concentrations. The effect of RRE on cell proliferation was measured by MTT assay and the effect of RRE on the production of nitric oxide (NO) was determined in the macrophage-like cell lines Raw264.7, C6 and peritoneal macrophages (pMQ).
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