Cloning of Pig Kidney cDNA Encoding an Angiotensin Ⅰ Converting Enzyme
2006
Yoon, J.H. (Dongguk University, Seoul, Republic of Korea) | Yoon, J.O. (Dongguk University, Seoul, Republic of Korea) | Hong, K.W. (Dongguk University, Seoul, Republic of Korea), E-mail: [email protected]
Angiotensin converting enzyme (ACE) is a zinc-containing dipeptidase widely distributed in mammalian tissues and is thought to play a significant role in blood pressure regulation by hydrolyzing angiotensin Ⅰ to the potent vasoconstrictor, angiotensin Ⅱ. Recently, the presence of ACE in pig ovary was reported and the ACE from pig kidney was isolated and characterized. However no nucleotide sequence of the ACE gene from pig is yet known. We report here the cloning of the ACE cDNA from pig kidney by using the reverse transcriptase-polymerase chain reaction.
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