Identification of a Peptide Enhancing Mucosal and Systemic Immune Responses against EGFP after Oral Administration in Mice
2006
Kim, S.H. (Chonbuk National University, Jeonju, Republic of Korea) | Lee, K.Y. (Chonbuk National University, Jeonju, Republic of Korea) | Kim, J. (Chonbuk National University, Jeonju, Republic of Korea) | Park, S.M. (Chonbuk National University, Jeonju, Republic of Korea) | Park, B.K. (Seoul National University, Seoul, Republic of Korea) | Jang, Y.S. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: [email protected]
Gangliosides are receptors for various peptides and proteins including neuropeptides, β-amyloid proteins, and prions. Recently, the role of gangliosides in mucosal immunization has attracted attention due to the emerging interest in oral vaccination. Ganglioside GM1 exists in abundance on the surface of the M cells of Peyer's patch, a well-known mucosal immunity induction site. In the present study we identified a peptide ligand for GM1 and tested whether it played a role in immune induction.
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