Metabolism of Ginsenoside Rg5, a Main Constituent Isolated from Red Ginseng, by Human Intestinal Microflora and Their Antiallergic Effect
2006
Shin, Y.W. (Kyung Hee University, Seoul, Republic of Korea) | Bae, E.A. (Kyung Hee University, Seoul, Republic of Korea) | Han, M.J. (Kyung Hee University, Seoul, Republic of Korea) | Kim, D.H. (Kyung Hee University, Seoul, Republic of Korea), E-mail: dhkim@khu.ac.kr
When ginsenoside Rg5, a main component isolated from red ginseng, was incubated with three human fecal microflora for 24 h, all specimens showed hydrolyzing activity: all specimens produced ginsenoside Rh3 as a main metabolite, but a minor metabolite 3β,12β-dihydroxydammar-21(22),24-diene (DD) was observed in two specimens. To evaluate the antiallergic effect of ginsenoside Rg5 and its metabolites, the inhibitory effect of ginsenoside Rg5 and its metabolite ginsenoside Rh3 against RBL-2H3 cell degranulation, mouse passive cutaneous anaphylaxis (PCA) reaction induced by the IgE-antigen complex, and mouse ear skin dermatitis induced by 12-O-tetradecanoilphorbol-13-acetate (TPA) were measured.
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