A Novel Mannose-binding Tuber Lectin from Typhonium divaricatum (L.) Decne (family Araceae) with Antiviral Activity Against HSV-Ⅱ and Anti-proliferative Effect on Human Cancer Cell Lines
2007
Luo, Yongting (Sichuan University, Chengdu, China) | Xu, Xiaochao (Sichuan University, Chengdu, China) | Liu, Jiwei (Sichuan University, Chengdu, China) | Li, Jian (Sichuan University, Chengdu, China) | Sun, Yisheng (Sichuan University, Chengdu, China) | Liu, Zhen (Sichuan University, Chengdu, China) | Liu, Jinzhi (Sichuan University, Chengdu, China) | Damme, Els Van (Ghent University, Belgium) | Balzarini, Jan (Katholieke University Leuven, Belgium) | Bao, Jinku (Sichuan University, Chengdu, China), E-mail: [email protected]
A novel mannose-binding tuber lectin with in vitro anti-proliferative activity towards human cancer cell lines and antiviral activity against HSV-Ⅱ was isolated from fresh tubers of a traditional Chinese medicinal herb, Typhonium divaricatum (L.) Decne by a combined procedure involving extraction, ammonium sulfate precipitation, ion exchange chromatography on DEAE-SEPHAROSE, CM-SEPHAROSE and gel-filtration on sephacryl S-200. The apparent molecular mass of the purified Typhonium divaricatum lectin (TDL) was 48 kDa.
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