Lipid Metabolism in Rats Fed Acetaminophen with Coadministration of Adzuki Bean Extract
2007
Han, K.H. (Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan) | Ohba, Kiyoshi (Hokkaido Tokachi Area Regional Food Processing Technology Center, Obihiro, Hokkaido, Japan) | Lee, C.H. (Konkuk University, Seoul, Republic of Korea) | Shimada, Ken-ichiro (Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan) | Sekikawa, Mitsuo (Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan) | Fukushima, Michihiro (Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan), E-mail: fukushim@obihiro.ac.jp
The effect of water extract of adzuki beans on acetaminophen-altered lipid metabolism was examined in rats. Control group of rats was fed a basal diet, another group of rats was fed 0.5% acetaminophen (APAP group), and a third group of rats was fed 0.5% acetaminophen plus 5% adzuki bean extract (ABE group) for 4 weeks. Serum total and HDL cholesterol levels in the APAP group were significantly lower than those in the control and ABE groups. Hepatic cholesterol 7α-hydroxylase and fatty acid synthase mRNA levels in the APAP and ABE groups were significantly higher and lower than in the control group, respectively.
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