Anti-inflammatory activities of a herbal preparation (HemoHIM) in colitis induced by trinitrobenzene sulfonic acid in rats
2007
Lee, H.J. (Chonnam National University, Gwangju, Republic of Korea) | Kim, S.R. (Chonnam National University, Gwangju, Republic of Korea) | Moon, C.J. (Chonnam National University, Gwangju, Republic of Korea) | Kim, J.C. (Chonnam National University, Gwangju, Republic of Korea) | Bae, C.S. (Chonnam National University, Gwangju, Republic of Korea) | Kang, S.S. (Chonnam National University, Gwangju, Republic of Korea) | Jung, U.H. (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea) | Park, H.R. (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea) | Jo, S.K. (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea) | Kim, S.H. (Chonnam National University, Gwangju, Republic of Korea), E-mail: shokim@chonnam.ac.kr
The cause and pathogenesis of inflammatory bowel disease remain unknown and no definite therapy exists until now. The present study was conducted to investigate the anti-inflammatory effects of a herbal preparation (HemoHIM) in colitis induced by 30 mg of trinitrobenzene sulfonic acid (TNBS) in rats. Sprague-Dawley rats were divided into 5 groups. Each group was treated with 1 mg of HemoHIM/ml of drinking water, 4 mg of HemoHIM/ml of drinking water, 50 mg of HemoHIM/kg of body weight (i.p. once every other day) or 100 mg/kg of HemoHIM of body weight (i.p. once every other day) from the next day.
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