Protective effects of mix-crude outer membrane protein Salmonella vaccine against salmonellosis in chickens and pigs
2007
Lee, H.S. (National Veterinary Research and Quarantine Service, Anyang, Republic of Korea), E-mail: leehsoo@nvrqs.go.kr | Lim, S.K. (National Veterinary Research and Quarantine Service, Anyang, Republic of Korea) | Cho, Y.S. (National Veterinary Research and Quarantine Service, Anyang, Republic of Korea) | Joo, Y.S. (National Veterinary Research and Quarantine Service, Anyang, Republic of Korea) | Kim, J.H. (National Veterinary Research and Quarantine Service, Anyang, Republic of Korea) | Kim, J.M. (National Veterinary Research and Quarantine Service, Anyang, Republic of Korea)
We investigated the safety, immunogenicity and protectivity of mix-crude outer membrane protein (cOMP) vaccine against salmonellosis in animals. The mix-cOMP vaccine was extracted from Salmonella enterica serovar Typhimurium (ST) and Salmonella enterica serovar Enteritidis (SE) and Salmonella enterica serovar Braenderup (SB) isolated from pigs. The mix-cOMP vaccine gave significantly higher antibody response than ST-bacterin and ST-cOMP vaccine in guinea pigs. The survival rates of mix-cOMP vaccinated groups showed significantly higher (100%) than those (0-20%) of unvaccinated control group, challenged with 3 species of Salmonella (ST, SE and SB) in mice.
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