In vitro Cytotoxic Effect of Extracts from Styela plicata
2007
Lee, B.B. (Kyungnam University, Masan, Republic of Korea) | Cha, M.R. (Kyungnam University, Masan, Republic of Korea) | Park, H.R. (Kyungnam University, Masan, Republic of Korea) | Lee, S.C. (Kyungnam University, Masan, Republic of Korea), E-mail: [email protected]
The present study describes the preliminary evaluation of the anticancer activity of Styela plicata. Freeze-dried S. plicata was extracted with methanol, ethanol, acetone, and water, and then anticancer effect of the extracts was measured by the MTT reduction assay and phase-contrast microscopy on the HT-29 human colon carcinoma cells. Among the extracts, acetone extract showed the highest anticancer activity. The cell proliferation rates markedly decreased by 94.0% at the concentration of 500 ㎍/mL of acetone extract compared with control cells.
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