Antiatherogenic effect of Nigella sativa L. (Kalonji) seeds in rabbits with experimentally-induced hypercholesterolemia
2007
Fatima, S. (Karachi Univ. (Pakistan). Dept. of Physiology) | Khan, N.I. (Karachi Univ. (Pakistan). Dept. of Physiology) | Naz, L. | Yasmeen, G. | Hajira, B. | Hussain, Z.
The present paper investigates the hypolipidemic effect of Nigella sativa L. administration on diet-induced hypercholesterolemia. Sixteen age-matched rabbits were divided into two experimental groups. Base line values of the requisite parameters were observed and animals were then administered atherogenic diet for four weeks. 100mg/kg of body weight/day N. sativa seed powder were fed to these hypercholesterolemic rabbits for another four weeks. At the end of experimental period, blood samples were collected and assayed for alterations. The administration of N. sativa seed powder in hypercholesterolemic animals significantly decreased plasma cholesterol, triglycerides and LDL-C concentrations and increased plasma HDL-C concentration. Beneficial effects were also observed on serum ALT, AST, glucose and GSH levels. These findings suggested cardioprotective effect of dietary supplementation of N. sativa.
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