Inhibitory effect of SRIH-14 on ACTH cells in neonatal female rats
2007
Milosevic. V.,Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Terzic, M.,University of Belgrade, Belgrade (Serbia). School of Medicine, Institute of Physiology | Manojlovic-Stojanoski, M.,Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Nestorovic, N.,Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Sekulic, M.,Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Starcevic, V.,University of Belgrade, Belgrade (Serbia). School of Medicine, Institute of Physiology
The purpose of this study was to examine the effects of administration of SRIH-14 on morphological and stereological parameters of adrenocorticotropic (ACTH) cells in neonatal female rats. The obtained results demonstrate that SRIH-14, applied multiply in the neonatal period, exerted an inhibitory influence on ACTH cell morphology in neonatal female rats. In conclusion, systemic application of SRIH-14 by the s.c. route produced a marked decrease in stereological parameters of the pituitary ACTH cells.
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