Quantitative structure-activity relationship of some 1-benzyl benzimidazole derivatives as antifungal agents
2007
Podunavac-Kuzmanovic, S.O., University of Novi Sad, Novi Sad (Serbia). Faculty of Technology | Barna, D.J., Institute of Public Health, Subotica (Serbia) | Cvetkovic, D.D., University of Novi Sad, Novi Sad (Serbia). Faculty of Technology
In the present study, the antifungal activity of some 1-benzylbenzimidazole derivatives against yeast Saccharomyces cerevisiae was investigated. The tested benzimidazoles displayed in vitro antifungal activity and minimum inhibitory concentration (MIC) was determined for all the compounds. Quantitative structure-activity relationship (QSAR) has been used to study the relationships between the antifungal activity and lipophilicity parameter, log P, calculated by using CS Chem-Office Software version 7.0. The results are discussed on the basis of statistical data. The best QSAT model for prediction of antifungal activity of the investigated series of benzimidazoles was developed. High agreement between experimental and predicted inhibitory values was obtained. The results of this study indicate that the lipophilicity parameter has a significant effect on antifungal activity of this class of compounds, which simplify design of new biologically active molecules.
显示更多 [+] 显示较少 [-]