Behavioural and endocrine responses of socially isolated rats to long-term diazepam treatment
2007
Dronjak, S., Vinca Institute of Nuclear Sciences, Belgrade (Serbia) | Spasojevic, N., Vinca Institute of Nuclear Sciences, Belgrade (Serbia) | Gavrilovic, Lj., Vinca Institute of Nuclear Sciences, Belgrade (Serbia) | Varagic, V., Faculty of Medicine, Belgrade (Serbia)
The effects of diazepam (0.2 mg/kg/ during 21 days, i.p. on behaviour, pituitary-adrenocortical and symphato-adrenomedullary system of socially isolated and group-housed adult male rats additionally exposed to immobilization, were studied. Social isolation led to a shorter duration of grooming and longer latency to start grooming. The obtained results show that chronic treatment with diazepam of socially isolated rats leads to changes in some parameters of grooming behaviour, decreasing at the same time only basal plasma ACTH level. Exposure to immobilization as an additional stressor produced the lowest increase of plasma ACTH in comparison with that observed in socially isolated rats treated with vehicle. The current data indicates that chronic treatment of socially isolated rats with a low diazepam dose did not significantly affect stress-related adrenomedullary and adrenocortical alterations.
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