Endothelium-dependent relaxation of rat aorta induced by resveratrol
2007
Gojkovic-Bukarica, Lj., School of Pharmacy, Belgrade (Serbia) | Novakovic, A., School of Medicine, Belgrade (Serbia) | Lesic, A., Clinical Center of Serbia, Belgrade (Serbia) | Bumbasirevic, M., Clinical Center of Serbia, Belgrade (Serbia)
The aim of this study was to investigate the mechanism(s) of resveratrol-induced vasorelaxation in rat aorta with endothelium present. Rat aortic rings were precontracted with phenylephrine. Resveratrol induced relaxation of the rat aortic rings. In conclusion, we have shown that resveratrol potently relaxed rat aortic rings with endothelium present. It seems that NO and smooth muscle Kv channels are included in this relaxation. This findigs is of clinical importance in both veterinary and human medicine.
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