Cell cycle kinetics and cytogenetic changes in human lymphocytes exposed to oestradiol in vitro
2006
Djelic, N., Faculty of Veterinary Medicine, Belgrade (Serbia) | Spremo-Potrarevic, B., Faculty of Pharmacy, Belgrade (Serbia) | Markovic, B., Faculty of Veterinary Medicine, Belgrade (Serbia) | Zivkovic, L., Faculty of Pharmacy, Belgrade (Serbia) | Djelic, D., Faculty of Veterinary Medicine, Belgrade (Serbia)
On the basis of obtained results it can be concluded that oestradiol has no significant influence on cell cycle kinetics and mitotic index of cultured human lymphocytes. However, at estradiol concentration of 7 x 10E-6 M, and at higher concentrations used in this experiment, there was a significant increase of gaps, breaks, and aneuploidies. On the other hand, oestradiol treatment has not changed the frequency of polyploid cells. Therefore, it can be concluded that high concentrations of oestradiol pose some genetic risk detectable at cytogenetic level.
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