Plasma pyruvic acid changes in Zebu cattle experimentally infected with Clostridium chauvoei
2007
Useh, N.M., Ahmadu Bello University, Zaria (Nigeria) | Amupitan, E. | Balogun, E.O. | Adamu, S. | Ibrahim, N.D. | Nok, A.J. | Esievo, K.A.N.
A study was carried out to investigate the pyruvic acid concentration in Zebu cattle experimentally infected with Clostridium chauvoei. In the experimental design, 14 Zebu bull-calves were divided into 4 groups namely: groups A, B, C and D, and administered C. chauvoei, toxins, neuraminidase and control respectively. There was pyruvate accumula- tion in the plasma of all but the control group and the mean pyruvic acid concentrations in the C. chauvoei, toxin and neuraminidase groups had some peaks, with the highest peak value in the neuraminidase-administered group, followed by C. chauvoei and toxin-administered groups in that order. The control group had no peak pyruvic acid concentration and the values were almost similar throughout the experimental period (P0.05). There was a statistically significant difference (P0.05) between the plasma pyruvic acid levels of C. chauvoei, neuraminidase, toxin-administered and control groups, respectively. The significance of pyruvate accumulation in the pathogenesis of blackleg is discussed.
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