The effect of cadmium on fatty acid absorption across the caecum epithelium in sheep
2006
Makova, Z.
The effect of cadmium as one of the heavy metals on acetate and propionate absorption across the caecum epithelium was investigated. In the experiment caecum walls obtained from adult Merino sheep two to four years old were used. Acetate and propionate absorption was observed on an apparatus constructed in our laboratory. Determination of the acids was carried out by gas chromatography (Perkin-Elmer 8500). Absorption of separately acetate (50 mmol.l-1 of Thyrode"s solution) and also in combination with propionate (50 + 15 mmol.l-1 of Thyrode"s solution) across the caecum epithelium after the addition of all three cadmium concentrations (5, 20, 50 mg) was increased. Propionate absorption was not effected. Only a 50 mg addition of cadmium to combined propionate with acetate decreased propionate absorption. One of the possible explanations of this phenomenon could be that cadmium readily enters into interactions with proteins and phospholipids which are important components of the cell membranes. In the case of propionate absorption a reason might be the higher metabolization rate in the epithelium.
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