The utilization of disk diffusion method and the Delvotest for determining synergistic effects of cephalosporin combinations in milk
2007
Kukurová, I.,Slovak University of Technology, Bratislava (Slovak Republic) | Hozová, B.
Antibiotics including beta-lactam antibiotics are used in veterinary practice for the treatment of mastitis in milking cows. This study suggests that a suitable combination of antibiotics may result in synergistic action that might cause reduction of dosages with subsequent decrease in the maximum residue limits (MRL) as specified by the European Economic Commission of the European Union and the United States Food and Drug Administration recommendations. This study used disk diffusion assay and tested various combinations of 6 cephalosporins (cefuroxime, cefamandole, cefazoline, cefoperazone, cefotaxime and ceftazidime) for synergistic activity. Two of the antibiotic combinations were also tested by means of Delvotest (The SP kit). In our model experiments with milk, an increase in antimicrobial activity indicating synergistic effect between tested cephalosporins was observed.
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