Inhibition of thioredoxin reductase by curcumin analogs
2008
Liu, Z.(Sun Yat-Sen Univ., Guangzhou (China)) | Du, Z.Y. | Huang, Z.S. | Lee, K.S. | Gu, L.Q.
Curcumin analogs were first investigated for their inhibitory effects on thioredoxin reductase (TrxR). Most of them were more potent TrxR inhibitors than natural curcumin. The structure-activity relationship was summarized, and the curcumin analog was found to inhibit TrxR irreversibly in a time-dependent manner. The action was caused by covalent modification of the redox-active residues Cyssup(497) and Secsup(498) in TrxR.
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书目信息
页码
pp. 2214-2218
其它主题
Oxirreducion; Synthese chimique; Sintesis quimica; Curcuma (epice); Curcuma (especia); Oxydoreduction
语言
英语
注释
Summary (En)
1 tab. 2 fig. 19 ref.
类型
Summary
2009-03-15
AGRIS AP