Disruption of lipid rafts enhances the effect of lactobacilli [Lactobacillus] on the production of tumor necrosis factor-alpha in mononuclear blood cells

Soria, M.; Mechoud, M.; Martin De Quevedo, A.; Font De Valdez, G.; Rodriguez, A.V.

Disruption of lipid rafts enhances the effect of lactobacilli [Lactobacillus] on the production of tumor necrosis factor-alpha in mononuclear blood cells

2008

Soria, M.(Center of Reference for Lactobacilos, Tucuman (Argentina)) | Mechoud, M. | Martin De Quevedo, A. | Font De Valdez, G. | Rodriguez, A.V.

We investigated, to determine whether disruption of lipid rafts would influence the effect of three selected strains of Lactobacillus on TNF-alpha production by peripheral blood mononuclear cells. Two strains increased TNF-alpha production; and the third one reduced cytokine levels. Disruption of rafts changed the immunomodulatory effect of the three strains. This is the first report on a potential role of rafts in lactobacilli-cell interaction.

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