Comparison of Antiplatelet Activities of Green Tea Catechins
2007
Cho, M.R. (Chungbuk National University, Cheongju, Republic of Korea) | Jin, Y.R. (Chungbuk National University, Cheongju, Republic of Korea) | Lee, J.J. (Chungbuk National University, Cheongju, Republic of Korea) | Lim, Y. (Chungbuk National University, Cheongju, Republic of Korea) | Kim, T.J. (Chungbuk National University, Cheongju, Republic of Korea) | Oh, K.W. (Chungbuk National University, Cheongju, Republic of Korea) | Yoo, H.S. (Chungbuk National University, Cheongju, Republic of Korea) | Yun, Y.P. (Chungbuk National University, Cheongju, Republic of Korea), E-mail: [email protected]
We have previously reported that green tea catechins (GTC) displayed potent antithrombotic effect, which was due to the antiplatelet activity. In the present study, the antiplatelet activity of each green tea catechin components was compared in vitro. Galloylated catechins including (-)-epigallocatechin gallate (EGCG), (-)-gallocatechin gallate (GCG), (-)-epicatechin gallate (ECG) and (-)-catechin gallate (CG), significantly inhibited collagen (5 ㎍/mL)-induced rabbit platelet aggregation with IC∧50 values of 79.8, 63.0, 168.2 and 67.3 μM, respectively.
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