Chromosomal Variations in Patients with Bipolar Affective Disorder
2007
Demirhan, Osman (Cukurova University, Adana, Turkey), E-mail: [email protected] | Tastemir, Deniz (Cukurova University, Adana, Turkey) | Ozpoyraz, Nurgul (Cukurova University, Adana, Turkey)
The study of cytogenetic abnormalities may lead to a more accurate localization of genes related to disease. Therefore, chromosome determination could be included among the routine investigations of patients with bipolar disorder. We have examined the chromosomes of 80 patients with bipolar disorder and 30 controls by using the GTG banding technique. Random numerical and structural variations were present in 26.3% of the patients and in 10% of the controls. Of these, 57.1% and 42.9% of abnormalities had structural and numerical aberrations, respectively.
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