Hepatoprotective effect of Grifola frondosa water extract on carbon tetrachloride-induced liver injury in rats
2008
Lee, J.S. (Yeungnam University, Gyeongsan, Republic of Korea) | Kim, H.S. (Yeungnam University, Gyeongsan, Republic of Korea) | Lee, Y.J. (Yeungnam University, Gyeongsan, Republic of Korea) | Yong, C.S. (Yeungnam University, Gyeongsan, Republic of Korea) | Choi, H.G. (Yeungnam University, Gyeongsan, Republic of Korea) | Han, G.D. (Yeungnam University, Gyeongsan, Republic of Korea) | Kim, J.A. (Yeungnam University, Gyeongsan, Republic of Korea) | Lee, J.S. (Yeungnam University, Gyeongsan, Republic of Korea), E-mail: [email protected]
The present study aimed at assessing the protective effect of water extract from fruit body of the Grifola frondosa (GFW) on carbon tetrachloride (CCl₄)-induced hepatotoxicity. Rats orally administered with GFW 0.5, 1.0, 2.0 g/kg for 14 days were treated with CCl₄ to induce hepatotoxicity. Pretreatment with GFW remarkably prevented the elevation of serum AST, ALT, ALP, LDH, γ-GTP, and liver lipid peroxides in CCl₄-treated rat and GFW administration in liver injured rats by CCl₄ showed significant (p less than 0.05) protection of liver as evidenced from normal serum enzymes and malondialdehyde (MDA) levels. In the ultrastructural changes, administration Of CCl₄-induced damage of hepatocytes with vacuolation, a highly damaged endoplasmic reticulum, and degenerating nuclei. However, pre-administration with GFW preserved normal ultrastructure of hepatocytes. These results suggest that GFW had an effect to inhibit CCl₄-induced liver injury in rat, and that it could be used as an effective hepatoprotective agent against chemical-induced liver damage.
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