Effects of Sweet Potato Fractions on Alcoholic Hangover and Gastric Ulcer
2008
Kim, J.J. (Chungbuk National University, Cheongju, Republic of Korea) | Kim, C.W. (Seoul National University, Seoul, Republic of Korea) | Park, D.S. (Chungbuk National University, Cheongju, Republic of Korea) | Shin, S.H. (Chungbuk National University, Cheongju, Republic of Korea) | Jeon, J.H. (Chungbuk National University, Cheongju, Republic of Korea) | Jang, M.J. (Chungbuk National University, Cheongju, Republic of Korea) | Ji, H.J. (Chungbuk National University, Cheongju, Republic of Korea) | O, N.G. (Chungbuk National University, Cheongju, Republic of Korea) | Song, J.G. (Chungbuk National University, Cheongju, Republic of Korea) | Lee, J.S. (Chungbuk National University, Cheongju, Republic of Korea) | Kim, B.Y. (Dongyangbiopia Inc., Hamyang, Republic of Korea) | Choi, E.K. (Seoul National University, Seoul, Republic of Korea) | Joo, S.S. (Chungbuk National University, Cheongju, Republic of Korea) | Hwang, S.Y. (Juseong College, Cheongwon, Republic of Korea) | Kim, Y.B. (Chungbuk National University, Cheongju, Republic of Korea), E-mail: [email protected]
Reddish purple-colored fruits and vegetables contain high level of anthocyanins, which are well known to exert antioxidant, cardioprotective and hepatoprotective actions. In the present study, the effects of sweet potato fermentation filtrate (SPF) and its fractions on alcoholic hangover and gastric ulcer were investigated. In order to evaluate antihangover effect, male Sprague-Dawley rats were orally administered with SPF (240 or 750 mg/kg) 30 min prior to or 60 min after oral challenge with 3 mL/㎏ of ethyl alcohol (15 mL/kg of 20% in water), and the blood concentration of alcohol were analyzed up to 5 hours. Pretreatment with 240 and 750 mg/kg of SPF significantly reduced the blood ethanol concentration by 20-25% and 50-60%, respectively, which was superior to the effect of the Hovenia dulis Thunb extract. In addition, posttreatment of SPF enhanced the alcohol-clearance rate to 2.8 and 3.1 folds at doses of 240 and 750 mg/kg, respectively. In comparison, liquid portion of SPF exerted similar antihanover effect to SPS, whereas the effect of purified anthocyanins was negligible, indicating that active ingredients are included in the liquid portion. For the assessment of antiulcer activity, fractions of SPF were orally treated 30 min before oral administration of absolute ethanol (3 mL/kg) and intravenous injection of 1% Evan's blue (0.5 mL/kg). One hour later, the ulcer index (mm of ulcer lesions) was measured, and dye leakage on the gastric wall was quantified by extracting the dye with formamide. SPF and its liquid portion (300 mg/kg) near-fully prevented the ethanol-induced gastric ulcer and significantly reduced the Evan's blue leakage, while the purified anthocyanins were ineffective. Among subfractions, buthanol fraction of SPF-liquid portion exerted a substantial antiulcer activity, which was superior to water and methanol fractions. Taken together, it was demonstrated that SPF possesses antihangover and antiulcer activities, and that buthanol fraction of SPF-liquid portion contains active ingredients. Therefore, it is suggested that SPF or its buthanol fraction could be a potential candidate for the attenuation of hangover and gastric ulcers induced by excessive drinking of alcohol, although the action mechanisms remain to be clarified.
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