Histological and immunohistochemical evaluations of rat soft tissue response to bioceramical implants
2009
Markovic, D., Faculty of Veterinary Medicine, Belgrade (Serbia) | Kojic, Z., School of Medicine, Belgrade (Serbia) | Marinkovic, D., Faculty of Veterinary Medicine, Belgrade (Serbia) | Danilovic, V., School of Dentistry, Belgrade (Serbia) | Radovanovic, A., Faculty of Veterinary Medicine, Belgrade (Serbia) | Janackovic, Dj., Faculty of Technology and Metallurgy, Belgrade (Serbia)
The purpose of this study was to evaluate the tissue response induced by bioceramical materials (BCM) implanted in rat subcutaneous tissue. In conclusion, the implant sides compared with surgical incision wounds induced a foreign body-type granuloma with subsequent fibrosis around the grafts. The presence of a capsule at the interface with BCM in rat subcutis did not elicit any remarkable immune responses, thus being considered biocompatible. By evaluating different responses according to BCM, the most intense tissue reaction was noticed at HAP45, graded as severe, and mild to moderate for DC, HAP22 and alfa tricaltium phosphate.
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