Confirmation of QTL underlying dairy production traits in Spanish Churra sheep | Confirmación de un QTL con efecto sobre caracteres de producción de leche en la raza ovina Churra
2009
García Gámez, E., Universidad de León (España). Facultad de Veterinaria | Gutiérrez Gil, B., Universidad de León (España). Facultad de Veterinaria | García Fernández, M., Universidad de León (España). Facultad de Veterinaria | Sánchez, J.P., Universidad de León (España). Facultad de Veterinaria | Fuente, L.F. de la, Universidad de León (España). Facultad de Veterinaria | San Primitivo, F., Universidad de León (España). Facultad de Veterinaria | Arranz, J.J., Universidad de León (España). Facultad de Veterinaria
After a preliminary genome scan carried out in Churra sheep to detect QTL influencing milk production traits, additional families are now been analyzed to confirm some of the identified effects. We present here the confirmation of the QTL located in chromosome 20 for fat percentage. This meta-analysis was performed adding 15 new families to the ones previously analyzed. The total number of animals was 2.054, distributed in 25 families, one of them common in both studies. Phenotypic measurements studied included milk yield, protein percentage and fat percentage (FP). All the population was genotyped for seven microsatellite markers evenly distributed across the studied chromosome. Response variables used in the QTL analysis were yield deviations, estimated from the phenotypic data corrected for fixed environmental effects. For the QTL analysis, a multimarker regression method was implemented through the GridQTL software. Chromosome-wise critical values were calculated through 10.000 permutations. The average information content across the chromosome was 0.70. An across-family association analysis confirmed a region on this chromosome carrying the QTL for FP at the 5% chromosome-wise level (p-value = 0.0309). The within-family analysis revealed 6 families segregating for the QTL. This confirmation is the previous stage of a fine-mapping approach of this QTL.
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