Field Evaluation of Long Term Immunity in Cattle Vaccinated Against Theileria annulata.
2008
Esma`il Niya, Kasra | Habibi, Gholam Reza | A`bdi Gudarzi, Mohammad | Bozorgi, Soghra | Najjar, E`sam
Bovine theileriosis due to Theileria annulata is the most important parasitic disease of cattle and an obstacle in development of animal husbandry economy in Iran. Vaccination against theileriosis is the most effective route of control and prevention of the disease. Theileria annulata vaccine has been produced in Razi Vaccine and Serum Research Institute for a long period in Iran and vaccinated cattle show good resistance to the disease for at least one year. But due to many factors, the amount of vaccine production is not sufficient for cattle population in Iran . so, evaluation of the period of protection can play an important role in the efficacy of this strategy in control of theileriosis. Dairy cattle from 7 conventional farms in endemic region of Bouin- Zahra, Ghazvin Province, were selected, numbered and took under observations. Two methods, including Theilerin Skin Delayed Type Hypersensitivity Test and ELISA Test were used as the indices of evaluation of Cell-Mediated and Humoral Immunity , and according to a programmed time table, it has been tried to evaluate the protective immunity in the periods of 1, 2 and 3 years after vaccination. The data were analyzed statisticallyand according to the results, Theilerin Skin Test could be an acceptable index with satisfactory sensitivity and specificity. But because of variety and loss of solidity in the results, ELISA was not reliable for this purpose, as there were good results at the period of first year after vaccination, but any reactions could not detected after that. Then, it seems that there is protective immunity in the second year after vaccination that Theilerin test could detect it but ELISA couldn't.
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