The Role of The Effects of Vitamin D Supplementation on Bone Mineral Density and Bone Mineral Content in Ovariectomized Rats Compensation in Rats
2008
Choi, M.J. (Keimyung University, Daegu, Republic of Korea), E-mail: [email protected] | Kim, S.M. (Keimyung University, Daegu, Republic of Korea)
The effects of vitamin D₃ supplementation on bone mineral density and bone mineral content in ovariectmized rats were investigated. Forty female Sprague-Dawley rats (body weight 180 g) were divided into two group, ovariectomy and Sham groups, which were each randomly divided into two subgroups that were fed casein and casein supplemented with vitamin D₃ diets. Bone mineral density (BMD) and bone mineral content (BMC) were measured using PIXImus (GE Lunar Co, Wisconsin, USA) in spine and femur on 6 weeks after feeding. Osteocalcin and urinary DPD crosslinks value were measured as markers of bone formation and resorption. The body weight gain and food efficiency ratio (FER) were higher in OVX groups than in Sham groups regardless of diets. Serum Ca concentration and urinary Ca excretion were higher in vitamin D₃ supplemented group than in casein group in Sham and OVX. Crosslinks values were higher in OVX groups than in Sham groups. Spine BMD and femur BMD of ovariectomy group were significantly lower than Sham groups, however vitamin D₃ supplemented groups were significantly higher than control groups in Sham and OVX. In conclusion, dietary vitamin D₃ supplementation on ovariectimized rats were significantly increased bone mineral density and bone mineral content in spine and femur.
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