Biological Activity of Extracts from Garden Sage (Salvia officinalis L.)
2008
Cho, Y.J. (Kyungpook National University, Sangju, Republic of Korea), E-mail: yjcho@knu.ac.kr | Ju, I.S. (Kyungpook National University, Sangju, Republic of Korea) | Yun, D.H. (Kyungpook National University, Sangju, Republic of Korea) | Chun, S.S. (Yeungnam University, Gyeongsan, Republic of Korea) | An, B.J. (Daegu Haany University, Gyeongsan, Republic of Korea) | Kim, J.H. (NIP Biotech, Munkyung, Republic of Korea) | Kim, M.U. (Gyeongbuk Institute for Marine Bio-Industry, Uljin, Republic of Korea)
The extracts from Salvia officinalis were studied for antioxidative activities and inhibitory activities against angiotensin converting enzyme (ACE) and xanthine oxidase (XOase). Total phenolic compounds were found as 22.28, 26.3, 24.63, and 28.22 mg/g in the water, 60% ethanol, 60% methanol and 60% acetone extracts, respectively. The antioxidant activities of Salvia officinalis extracts were measured as 64.4±1.5% at 200 ㎍/ml on EDA, inhibition rate on ABTS of 96.9±0.2%, antioxidant protection factor of 2.30±0.16 PF and TBARS was 0.62±0.05 (×100 μM) in the control and 0.28±0.02 (×100 μM) in 60% ethanol extracts. Inhibitory activities was the ACE of 75.50% and XOase 100% in 60% ethanol extracts. The 60% ethanol extracts from Salvia officinalis exhibited antimicrobial activities against Helicobacter pylori such as 13 mm of clear zone and inhibition rate of 63.4% with 200 ㎍/ml of phenolics content. Rosemarinic acid was the most abundant phenolic compounds as analyzed by HPLC. The results suggest that the 60% ethanol extracts from Salvia officinalis L. will be useful as natural antioxidants and functional foods.
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