Medical imaging and immunohistochemical diagnosis of gastrointestinal stromal tumor originated from colon in a dog
2008
Choi, J.H. (Haemaru Referral Animal Hospital, Seongnam, Republic of Korea) | Kim, H.W. (Haemaru Referral Animal Hospital, Seongnam, Republic of Korea) | Lee, H.K. (Haemaru Referral Animal Hospital, Seongnam, Republic of Korea) | Kim, J.Y. (Seoul National University, Seoul, Republic of Korea) | Yoon, J.H. (Seoul National University, Seoul, Republic of Korea), E-mail: heeyoon@snu.ac.kr
Gastrointestinal stromal tumor (GIST) is one of the mesenchymall tumors originated from gastrointestinal submucosa. A 10 year-old, male, mixed breed dog with persistent diarrhea, anorxia and lethargy was referred to Haemaru Animal Referral Hospital. Large mass originated from the transverse colon was observed and large amount of ascites and free gas were found on abdominal radiography and ultrasonography. The ascites was septic exudate mixed with bacteria that consisted with intestinal perforation. These was no metastatic lesion. This mass was tentatively diagnosed as adenocarcinoma, leiomyosarcoma (LMS) and lymphosarcoma and surgical resection and histilogical examination were planned. However, according to owner's request, the patient was euthanized and then the necropsy was performed. About 10 cm sized mass originated from the cecum, ascending colon and transverse colon was adhered to surrounding mesentery and the perforation and large amount of asicites were observed. GIST was suspected on histopathologic examination and confirmed according to CD117 expression in immunohistochemistry. GIST, derived from interstitial cells of Cajal, can be distinguished from LMS and leiomyoma (LM) on the basis of expression of CD117 (KIT) immunohistochemically. GIST has a different biological behavior and clinical course compared with LMS and LM, therefore definite diagnosis for GIST using immunohischemistry is clinically important to predict the precise prognosis of the patient.
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