The Anti-Melanogenic Effects of Petalonia binghamiae Extracts in α-Melanocyte Stimulating Hormone-Induced B16/F10 Murine Melanoma Cells
2009
Yoon, H.S., Subtropical Horticulture Research Institute, Jeju, Republic of Korea | Koh, W.B., Faculty of Biotechnology, College of Applied Life Sciences, Jeju, Republic of Korea | Oh, Y.S., Jeju National University, Jeju, Republic of Korea | Kim, I.J., Subtropical Horticulture Research Institute, Jeju, Republic of Korea
Petalonia binghamiae extracts (PBE) suppressed melanin synthesis in a dose-dependent manner in α-melanocyte stimulating hormone (α-MSH)-treated B16/F10 murine melanoma cells. Specifically, the cell tyrosinase activity and melanin content were inhibited by 72% and 48%, respectively, in response to treatment with 100 ㎍/mL of PBE. The results of western blot analysis suggest that PBE induced the inhibition of tyrosinase and TRP-1 protein expression through suppression of α-MSH induced p38 and ERK activation.
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