Risk factors and biochemical variations in patients with ischemic stroke
2009
Naz, L. (Karachi Univ. (Pakistan). Dept. of Physiology) | Hussain, Z. (Karachi Univ. (Pakistan). Dept. of Physiology) | Husain, T. (Abbasi Shaheed Hospital, Karachi (Pakistan). Dept. of Medicine)
There has been much interest in homocysteine (Hcy) as an important risk factor for vascular diseases including stroke, independent of the long-recognized factors like hyperlipidemia, hypertension, diabetes mellitus, and smoking, although its association was described many decades ago. During the last decade, numerous studies observed a strong positive correlation between hyperhomo-cysteinemia and ischemic stroke, while others could not establish the same. The present study was, hence, planned to explore an association between Hcy levels in Pakistani patients with ischemic stroke in view of the limited data available, so that some practical recommendation for screening and treatment of this modifiable risk factor could be provided. The patients were categorized into several groups on the basis of the major risk factors involved. Hypertension, diabetes, high cholesterol, cigarette smoking, atrial fibrillation, and previous stroke or TlAs were th e major risk factors in these patients. The biochemical changes studied in several groups of stroke patients were homocysteine (Hcy; mumol/g), albumin(g/dL), hemoglobin (Hb;g/dL), and total cholesterol (mg/dL). No significant change was obtained in most of the comparisons except significant variation of homocysteine level (p less than 0.05) in stroke patients with previous stroke and TlAs. Determination of levels of Hcy in patients with ischemic stroke and age and sex-matched controls provide us knowledge about whether Hcy vary at different time periods following stroke. This investigation, hence, might be helpful in assessing the association of Hcy with stroke severity, outcome, recurrence, etiology, infarct volume, or risk factors.
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