Chemotherapeutic role of bis 3-azophenyl-4-hydroxy-67- methyl- 2H-pyran-2-one iron (II) in chemically induced skin cancer in albino rats
2006
Shahid, S. (Punjab Univ., Quaid-e-Azam Campus, Lahore (Pakistan). Inst. of Chemistry) | Iqbal, J. (Punjab Univ., Quaid-e-Azam Campus, Lahore (Pakistan). Inst. of Chemistry) | Mughal, M.S. (Government Coll. Univ., Lahore (Pakistan). Dept. of Zoology)
The present study was designed to see the effect of bis 3- Azophenyl-4-Hydroxy-6-Methyl-2-H-Pyran-2-one iron (II) (complex) in (DMBA), 7, 12 Dimethylbenz [a] Anthracene followed by 12-O-Tetradecanoyl-phorbal-13-Acetate, (TPA) induced tumours on the skin of albino rats. Eighty albino rats were divided into four groups. Groups A & B were used as control. DMBA was given to group C 100mug/ml as single dose along with @ TPA 10mug/ml in acetone twice a week. In-group D all the chemical carcinogens (DMBA & TPA) were applied locally in the same dose, route and schedule, after the induction of skin cancer, the complex (bis 3-Azophenyl-4-Hydroxy-6-Methyl-2H-Pyran-2-one iron (11) was applied by the same route followed by study of therapeutic role.
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