Immune-related health-relevant changes in the natural populations of Norway rat (Rattus norvegicus Berkenhout, 1769): white blood cells count, leukocite activity, and peripheral organ infiltration
2009
Kataranovski, M.V., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia). Department of Ecology | Radovic, D.L., Ministry of Environemnet and Land use Planning, Belgrade (Serbia). Department of Air Protection | Zolotarevski, L.D., Military Medical Academy, Belgrade (Serbia). Institute for Toxicology | Popov, A.D., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia). Department of Pathology | Kataranovski, D.S., University of Belgrade, Belgrade (Serbia). Faculty of Biology, Institute of Zoology
Basic immune-related health-relevant changes (total and differential white blood cell counts and activity, leukocyte tissue inflammation, and related pathohistology) were assessed in wild Norway rats from urba habitats. Comparative measurements were conducted in individuals of several laboratory strains of Norway rat in order to gain insight into environmental effects on the health of wild rats. Changes in leukocyte counts and activity along with tissue infiltration were noted only in wild rats, indicating systematic as well as tissue inflammation in these animals. Coincidence of these changes with chronic inflammatory pulmonary and kidney disease was observed in the majority of affected rats.
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