Influence of bile acids on drug transportation processes in vitro. [Doctoral dissertation] | Uticaj zucnih kiselina na transportne procese odabranih lekova u in vitro eksperimentima. Doktorska disertacija
2008
Posa, M.
In this work, effects of bile acids which form molecular aggregates (micelles, mixed micelles, hydrogen complex, etc.) on transportation processes were investigated. Influence of temperature on critical micellar concentration of cholic, deoxyholic and henodeoxycholic acids and its keto derivatives was examined. Also, micelle formation entropy was determined. This is very important parameter for self-association of bile acids and their interactions with hydrophobic molecules. Hydrogen complex of lidocain and bile acids was investigated and regression equation which connects structural parameters of bile acids and equilibrium constant of forming this complex was established. After that, effects of bile acids on transfer kinetics of lidocaine and verapamil from aqueous phase to chlorophorm was investigated. Also, micellar solubilization of lecithin and cholesterol by bile acids was determined.
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