The effect of SRIH-14 or octreotide on the morphological characteristics of adrenal medulla using newCAST
2010
Trifunovic, S., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Filipovic, B., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Ajdzanovic, V., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Manojlovic-Stojanoski, M., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Nestorovic, N., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Sekulic, M., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Milosevic, V., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia)
The effects of chronic treatments with either SRIH-14 or octreotide on the adrenal medulla of male Wistar rats were examined. Adult males received subcutaneous (s.c.) injections of 20 microgram/100 g body weight of either SRIH-14 or octreotide twice a day for 28 consecutive days. The absolute weights and the absolute volumes of the adrenal glands significantly decreased after either treatment. The adrenal medulla was analyzed by histological and stereological methods using newCAST. Compared to the control, the relative volumes of the vascular tissues significantly decreased - by 40% and 25% in the SRIH-14 and octreotide-treated groups, respectively. In the SRIH-14 and octreotide-treated groups the relative volumes of chromaffin and interstitial tissue increased by 6% and 5%, respectively. These findings show that both SRIH-14 and octreotide affect the morphological characteristics of the adrenal zona medullaris in a similar manner.
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