Glutathione status in the blood of rats after reticulocytosis induced by phenylhydrazine and bleeding
2010
Marković, S.D., Faculty of Science, Kragujevac (Serbia) | Obradović, A.D., Faculty of Science, Kragujevac (Serbia) | Žižic, J.B., Faculty of Science, Kragujevac (Serbia) | Ognjanović, B.I., Faculty of Science, Kragujevac (Serbia) | Štajn, A.Š., Faculty of Science, Kragujevac (Serbia) | Saičić, Z.S., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Spasić, M.B., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia)
In this experiment, we compared the in vivo effects of phenylhydrazine (PHZ) and bleeding treatment on the redox status and glutathione antioxidative mechanism parameters in the plasma and red blood cells (RBC) of rats. Results showed a lower level of reactive oxygen species (ROS), a higher level of lipid peroxidation and the effective antioxidative role of the glutathione system in the blood of bleending rats. PHZ-treatment induced higher concentrations of ROS and an accumulation of oxidized glutathione in the plasma, while the glutathione system showed a satisfactory antioxidative capacity in the RBC of rats. When comparing the two anemic groups, the PHZ-treated rats showed marked oxidative stress in the plasma.
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