Секреторные белки микроспоридии Paranosema locustae и их участие в патогенном воздействии на организм перелетной саранчи Locusta migratoria
2010
Dolgikh, V.V. | Pavlova, O.A. | Senderskij, I.V., All-Russia Research and Development Inst. of Plant Protection, St. Petersburg (Russian Federation) | Pehn, G.
There was performed an analysis of nucleotide sequences of genome of microsporidia Paranosema (Nosema, Antonospora) locustae – high pathogenic parasite of migratory locust to seek for protein-coding sequences potentially involved in the parasite-host relations. An analysis in genome P. locustae has found some secretory proteins capable of participating in pathogenesis and influencing the organism of host insect. N-terminal signal sequences responsible for secreting proteins were detected in some hydrolases. It is supposed that microsporidia can release molecular chaperones into the cytoplasm in the host cell. At he same time in genome of P. locustae 10 genes were detected encoding the affinity group of proteins enriched in leucine repeats comprising a secretory signal peptide but not comprising hydrophobic domains. Among genes of P. locustae potentially involved in the parasite-host relations 2 sequences were observed encoding carbohydrate recognizing lectin similar to the ricin B-chain, and ricin-like lectin having similarity to the C-subunit of bacterial cytolethal toxins. For both proteins the presence of signal peptide responsible for their secretion is predicted.
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