Pharmacocinetics of enrofloxacin after intravenous anf intramuscular injection in sheep | Фармакокинетика на енрофлоксацин след венозно и мускулно инжектиране на овце
2009
Dimitrova, D.., Thracian University, Stara Zagora (Bulgaria) | Dimitrov, D., Thracian University, Stara Zagora (Bulgaria) | Tsoneva, D., Bulgaria Drug Agency, Sofia (Bulgaria)
The aim of the present study is to investigate the pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin after single intravenous and muscle injection healty sheep. There were used 6 Stara Zagora sheep, with body weight between 40 and 42 kg. The enrofloxacin as a hydrochloride salt was applied at a dose of 5 mg/kg for the both ways of administration. Blood samples were collected before and after the injection of the quinolone at 0.08, 0.17, 0.25, 0.50, 1, 2, 3, 4, 6, 8, 10, 12 and the 24-th h. The plasma consentrations of and its metabolite were determined using a high efficiency liquid chromatograph. The pharmacokinetic parameters were determined with the use of a computer software TopFit v. 2.0 following the compartment and noncompartment method.
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