Antoioxidant activity of carboxymethyl chitosan with different substituting degrees
2008
Yao Qian | Sun Tao | Zhou Dongxiang | Mao Fang
Objective] In order to study the relations among different positions, degrees of substitution and antioxidant ability. [Method] N, O-carboxymethyl chitosan（NOA, NOB and NOC）with various degrees of substitution (DS) were obtained by etherizing chito-oligosacchaside. Their structure and substituted degree were characterized and their antioxidant activity to • OH was evaluated. [Result] The IC50s of NOA, NOB and NOC were 0.15, 0.29, 0.23 mg/ml while their DSs of CNH2 position(DSN) were 0.51, 0.29 and 0.38 and DSO were 0.74, 0.84, 0.97 respectively. [Conclusion] With the increase of DSN, antioxidant activity of N,O-carboxymethyl chitosan oligosaccharide to • OH was up.
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