Effect of sulphachloropyrazine on antioxidative systems in blood and liver of broilers
2011
Kostadinovic, L.M.,Megatrend Univ., Belgrad (Serbia). Faculty of Biofarming | Pavkov, S.T.,Institute for Medicinal Plants Research Dr. Josif Pancic, Belgrade (Serbia) | Levic, J.D.,Institute for Food Technology, Novi Sad (Serbia) | Galonja-Coghill, T.A.,Megatrend Univ., Belgrad (Serbia). Faculty of Biofarming | Dozet, G.K.,Megatrend Univ., Belgrad (Serbia). Faculty of Biofarming | Bojat, N.C.,Megatrend Univ., Belgrad (Serbia). Faculty of Biofarming
This report describes the effects of therapeutic doses of coccidiocid sulphachloropyrazine on enzymatic and non-enzymatic antioxidative systems in haemolysed blood and liver homogenate from broilers (glutathione, glutathione reductase, glutathione peroxidase, peroxidase, superoxide dismutase, xantine oxidase and lipid peroxidation). The in vivo investigation was carried out on 120 heavy-line broilers (Arbor acres) of both sexes. One-day-old broilers were randomly distributed into 2 groups, each numbering 60 individuals of both sexes: 1) control group; 2) group of broilers inoculated with laboratory derived coccidia species on the 21st day-of-age. When symptoms of coccidiosis appeared (30th day-of-age), blood sampling and decapitation of 20 chickens were carried out. The remaining broilers were treated with therapeutic doses of sulphachloropyrazine (60 ppm). Decapitation of 20 chickens was carried out after the therapy (38th day-of-age). Infection of broilers with coccidia intensified free radical processing in haemolysed blood and liver homogenate. This was evident from the increased levels of lipid peroxidation and the catalytic activity of almost all examined enzymes. Therapeutic doses of sulphachloropyrazine inhibited free-radical activity induced by disease.
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