c-Myc expression pattern in canine mammary and human breast cancer
2009
Pawaiya, R.V.S. | Ramkumar
Study on histopathological characterization as well as c-Myc expression pattern was undertaken in 15 canine mammary tumours and two human breast cancers by immunohistochemical method employing monoclonal antibodies. Of 15 canine mammary tumours, 4 were benign and 11 were malignant, while both human breast cancers were diagnosed as malignant. Benign cases included adenomas and benign mixed tumours while malignant neoplasms included mammary adenocarcinomas (acinar/ infiltrative/ papillary/ solid types), squamous cell carcinomas and malignant mixed mammary tumours. Two human breast cancers were diagnosed as infiltrative ductal carcinoma and intraduct cribriform carcinoma. Microscopically, infiltrative acinar adenocarcinoma of bitch mammary gland and infiltrative ductal carcinoma of human breast shared similar histological features. immunohistochemistry for c-Myc oncoprotein generally revealed strong nuclear and cytoplasmic immunolabelling in malignant tumours excepting in an adenoma case where glandular epithelial cells in some localities exhibited strong nuclear signals. The results of strong c-Myc immunolabelling pattern in infiltrative ductal carcinoma of human breast resembled to its canine counterpart, which suggested the involvement of similar molecular and pathological processes in the development and progression of tumours.
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