Inhibitors of Nitric Oxide Production from Artemisia princeps
2010
Li, Dayu, Chungbuk National University, Cheongju, Republic of Korea | Han, Xiang Hua, Chungbuk National University, Cheongju, Republic of Korea | Hong, S.S., Chungbuk National University, Cheongju, Republic of Korea | Lee, C., Chungbuk National University, Cheongju, Republic of Korea | Lee, M.S., Chungbuk National University, Cheongju, Republic of Korea | Lee, D.H., Korea University, Seoul, Republic of Korea | Lee, M.K., Chungbuk National University, Cheongju, Republic of Korea | Hwang, B.Y., Chungbuk National University, Cheongju, Republic of Korea
The chromatographic separation of a methanol extract of Artemisia princes led to the isolation of two sesquiterpene lactones, artecanin (1) and canin (2), together with a flavonoid, eupatilin (3). Their structures were determined by 1D, 2D-NMR and MS data analysis. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1 - 3 inhibited nitric oxide production with IC∧50 values of 19.5, 20.4 and 25.1 μM, respectively.
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