Evaluation of Efficacy of Bacteriophage CJø07 against Salmonella enteritidis Infection in the SPF Chicks
2010
Lim, T.H., Konkuk University, Seoul, Republic of Korea | Lee, H.J., Konkuk University, Seoul, Republic of Korea | Kim, M.S., Konkuk University, Seoul, Republic of Korea | Kim, B.Y., Konkuk University, Seoul, Republic of Korea | Yang, S.Y., BIO-Research Institute, CJ Cheiljedang Co., Seoul, Republic of Korea | Song, C.S., Konkuk University, Seoul, Republic of Korea
In the present study we report in vivo inhibitory potential of single strain of bacteriophage (CJø07) in day-old SPF chicks experimentally infected with Salmonella enteritidis (SE). The bacteriophages prepared by feed additives and drinking water were given to chicks for 20 days starting prior 10 days before challenge with SE. Chicks were euthanized at 10 days after challenge for quantitative salmonella isolation from intestine and determination of environmental contamination level of salmonella. Bacteriophage therapy as additives in feed and drinking water resulted in significant inhibition of the SE replication in intestines of SPF chickens (P less than 0.05). In addition, environmental contamination by SE fecal shedding was decreased in bacteriophage-treated birds. Therefore, bacteriophage CJø07 examined in this study may be a plausible alternative to antibiotics for the reduction of salmonella infection both in poultry.
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