The effect of chlorhexidine on the receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) expression in chronic periodontitis in humans and companion animals
2010
Janković, S., University of Belgrade, Belgrade (Serbia). School of Dentistry | Aleksić, Z., University of Belgrade, Belgrade (Serbia). School of Dentistry | Nikolić-Jakoba, N., University of Belgrade, Belgrade (Serbia). School of Dentistry | Stanimirović, D., University of Belgrade, Belgrade (Serbia). School of Dentistry | Stojić, Ž., University of Belgrade, Belgrade (Serbia). School of Dentistry | Pucar, A., University of Belgrade, Belgrade (Serbia). School of Dentistry | Hadži-Mihailović, M., University of Belgrade, Belgrade (Serbia). School of Dentistry
Periodontal disease is a chronic, multi-factorial disease of the tissue supporting the teeth. Periodontitis in companion animals is an almost identical disease to that in humans in terms of disease course and clinical preservation. Receptor activator of NK-kB ligand (RANKL) and osteoprotegerin (OPG) are bioactive molecules that control bone resorption. This study aims to evaluate the effect of Chlorhexidine (CXD) on the RANKL and OPG expressions in gingival crevicular fluid (GCF) collected from subjects with chronic periodontitis. In an existing inflammatory response, chlorhexidine reduced the level of periodontal inflammation, which leads to reduction of RANKL/OPG relative ratio. Decrease of RANKL/OPG ratio will apparently induce maintenance of alveolar bone and slow down periodontal tissue breackdown.
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