Protective effects of orally applied fullerenol nanoparticles in rats after a single dose of doxorubicin
2011
Ičević, I.Dj., Faculty of Sciences, Novi Sad (Serbia) | Vukmirović, S.N., Faculty of Medicine, Novi Sad (Serbia) | Srđenović, B.U., Faculty of Medicine, Novi Sad (Serbia) | Sudji, J.J., The Institute for the Health Protection of Workers Novi Sad, Novi Sad (Serbia) | Djordjević, A.N., Faculty of Sciences, Novi Sad (Serbia) | Injac, R.M., Faculty of Pharmacy, Ljubljana (Slovenia) | Vasović, V.M., Faculty of Medicine, Novi Sad (Serbia)
Polyhydroxylated, water soluble, fullerenol C60(OH)24 nano particles (FNP) in vitro and in vivo models, showed an expressive biological activity. The goal of this work was to investigate the potential protective effects of orally applied FNP on rats after a single dose of doxorubicin (DOX) (8 mg/kg (i.p.)) 6 h after the last application of FNP. After the last drug administration, the rats were sacrificed, and the blood and tissues were taken for the analysis. Biochemical and pathological results obtained in this study indicate that fullerenol (FNP), in H2O:dimethyl sulfoxide (DMSO) (80:20, w/w) solution given orally in final doses of 10, 14.4, and 21.2 mg/kg, three days successively, has the protective (hepatoprotective and nephroprotective) effect against doxorubicin-induced cytotoxicity via its antioxidant properties.
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