Dry olive leaf extract (DOLE) down-regulates the progression of experimental immune-mediated diabetes by modulation of cytokine profile in the draining lymph nodes
2011
Saksida, T., Institute for Biological Research Siniša Stanković, Belgrade (Serbia) | Miljković, D., Institute for Biological Research Siniša Stanković, Belgrade (Serbia) | Dekanski, D., Galenika, Belgrade (Serbia). Institute for Research and Development, Biomedical Research | Stojanović, I., Institute for Biological Research Siniša Stanković, Belgrade (Serbia) | Stošić-Grujičić, S., Institute for Biological Research Siniša Stanković, Belgrade (Serbia)
We have recently demonstrated the beneficial effects of dry olive leaf extract (DOLE) in two preclinical models of type 1 diabetes. Here we analyze the potential mechanisms underlying diabetes amelioration at the level of lymph node drainage. Treatment of C57BL/6 mice with DOLE during induction of diabetes with multiple low doses of streptozotocin (MLD-SZ) modulated cytokine expression and production in pancreatic lymph node cells, thereby changing the balance between potentially pathogenic and down-regulating cytokines. These results support the immunoregulatory potential of DOLE which takes place at the level of lymph node drainage and preserves the target tissue from autoimmune attack.
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